Effect of Placental Histological Chorioamnionitis and Prenatal Steroids on the Nervous System of Preterm Infants

Background: The placenta, as a link between mother and fetus, is closely related to the development of fetal nervous system. Histological chorioamnionitis (HCA) common placental inflammation an important factor in triggering premature delivery. Anabolic steroid (AS) medication promote lung maturity. Therefore, this study investigated relationship HCA, AS, brain injury infants. Objectives: This research aimed explore correlation pathological changes HCA prenatal use AS with preterm Methods: In total, 339 infants gestational age under 34 weeks were taken subjects, placenta was examined by pathology after samples divided into HCA+ AS+, AS-, HCA- AS- groups based on results hormones. occurrence level inflammatory indicators 2 h birth compared groups. Results: incidence group higher than (χ2 = 5.713, P < 0.05), AS+ 4.368, 0.05); AS-groups significantly 6.105, 0.013; χ2 9.086, 0.003; 4.848, 0.047, respectively). highest (30%). When procalcitonin 0.213 ng/mL, sensitivity predict 70.7%, specificity 80.2%. Conclusions: Brain damage insufficient treatment before more likely occur when both factors exist.